Yes, you can combine Adsterra ads with ads from any other network including Adsence. Keep in mind not to over saturate your website with excessive ads.
How multiple ads from different ad networks can affect your earnings
Also, you have to be especially precise with placing ads this way regardless of the ad format, and here is why:
It may eventually lead to a CPM drop
Imagine you are running ads from 2 networks (Network A and Network B) on the same page. In both of the networks, there are advertisers who set high bids in order to get 1st click traffic — that is the traffic of the highest quality. When high-bidding advertisers from Network A who expect to get 1st click traffic would eventually get a 2nd click one, just because advertisers from Network B bid higher and get all the 1st click one. 2nd click traffic has a lower quality, so Network A advertisers would eventually lower their spending which is no good for you as a publisher. In the worst-case scenario, advertisers may even blacklist your website and stop buying traffic, which may drastically hit your profit.It may lead to ad blindness
If you place too many ad slots on your page and fill it with ads to make a fast profit, such strategy eventually makes users blind to the ads. Besides, advertisers who are ready to pay for impressions might get displeased with the traffic quality and eventually switch to the CPA model — at this point, the above-mentioned scenario may happen.Code conflict
Several scripts from various networks running simultaneously may conflict causing page load issues, impressions lost.
Plus you should keep in mind that Chrome can open only 1 popunder on a click so 2nd popunder will be blocked by Chrome
How to avoid troubles with using ad codes from different ad networks
Test ad networks one after another, eventually selecting maximum 2 best performing ones
Regularly check your page performance metrics using Google PageSpeed Insights, PageSpeed Module, GTmetrix, and GTmetrix plugin for WordPress